The Sainte-Anne River is a river in the province of Quebec, Canada. It is a tributary of the Saint Lawrence River.
It is well known for ice fishing, with the primary catch being Tommy Cod, (poulamon in French), during the winter at Ste-Anne-de-la-Pérade. A small village builds up from the end of December to mid-February.
It is also regionally known for flooding, especially in St-Raymond, and sometimes in St-Casimir.
The river has its source in the Reserve des Laurentides and flows through St-Raymond, St-Casimir and Ste-Anne-de-la-Pérade to empty into the north shore of the Saint Lawrence.